The one that got away: Targeted therapy (gun) are very good at eliminating most of the tumor cells (light green/white) in cancer patients. However, a few cells (blue) bypass the drug treatment, develop resistance, resulting in their uncontrolled prol

The one that got away: Targeted therapy (gun) are very good at eliminating most of the tumor cells (light green/white) in cancer patients. However, a few cells (blue) bypass the drug treatment, develop resistance, resulting in their uncontrolled proliferation (red). Art by: Whitney Wong; Direction: Yogesh Goyal

Barcode Em All: We develop barcode-based lineage tracing systems that can uniquely label and longitudinally track the responses of millions of individual cells to stimuli.

Barcode Em All: We develop barcode-based lineage tracing systems that can uniquely label and longitudinally track the responses of millions of individual cells to stimuli.

The many paths to resistance: Resistant colonies emerging from treatment of cancer cells with targeted therapy exhibit molecular and phenotypic heterogeneity. Here Magenta color represents mRNA of ACTA2, a marker of smooth muscles.

The many paths to resistance: Resistant colonies emerging from treatment of cancer cells with targeted therapy exhibit molecular and phenotypic heterogeneity. Here Magenta color represents mRNA of ACTA2, a marker of smooth muscles.

single molecule RNA FISH: visualization of individual RNA molecules (white) of a particular gene in a field of cells stained for nuclei (blue).

single molecule RNA FISH: visualization of individual RNA molecules (white) of a particular gene in a field of cells stained for nuclei (blue).

Pre 2017: Developmental signals during Drosophila embryogenesis

 

Inverse time: [Taken from Developmental Cell] The ability to control when and where a signaling pathway is activated in the embryo has been a long-standing challenge in developmental biology. With optogenetics, this possibility is illustrated in Drosophila adults (white), larvae (light blue), and embryos (multiple colors), arranged as on the cover of Pink Floyd’s album The Dark Side of the Moon. [by Heath Johnson, Yogesh Goyal, and Jared Toettcher]

Inverse time: [Taken from Developmental Cell] The ability to control when and where a signaling pathway is activated in the embryo has been a long-standing challenge in developmental biology. With optogenetics, this possibility is illustrated in Drosophila adults (white), larvae (light blue), and embryos (multiple colors), arranged as on the cover of Pink Floyd’s album The Dark Side of the Moon. [by Heath Johnson, Yogesh Goyal, and Jared Toettcher]

Fruit Fly Factories: Cross-sections of ten ovarioles from different female fruit flies are arranged with stem cells and early stage egg chambers at the center, and the more mature chambers at the periphery. The nucleus of each cell is stained yellow/orange. The cell membranes are stained blue. [by Yogesh Goyal, Bomyi Lim, Miriam Osterfield, and Stanislav Shvartsman]

Fruit Fly Factories: Cross-sections of ten ovarioles from different female fruit flies are arranged with stem cells and early stage egg chambers at the center, and the more mature chambers at the periphery. The nucleus of each cell is stained yellow/orange. The cell membranes are stained blue. [by Yogesh Goyal, Bomyi Lim, Miriam Osterfield, and Stanislav Shvartsman]

Paint by light: Here, in an optogenetic fly embryo, light is used to paint artificial signaling patterns using the embryo as a canvas. [By Heath Johnson and Yogesh Goyal]

Paint by light: Here, in an optogenetic fly embryo, light is used to paint artificial signaling patterns using the embryo as a canvas. [By Heath Johnson and Yogesh Goyal]

The flying football: The gene Orthodenticle is essential for the development and patterning of the head, eyes and central nervous system of the fruit fly. Here, fly embryos are stained for nuclei (brown) and Orthodenticle (white).  The embryonic pattern mimics white stripes marked on an American football used in the national football league (NFL). [By Yogesh Goyal and Heath Johnson]

The flying football: The gene Orthodenticle is essential for the development and patterning of the head, eyes and central nervous system of the fruit fly. Here, fly embryos are stained for nuclei (brown) and Orthodenticle (white).  The embryonic pattern mimics white stripes marked on an American football used in the national football league (NFL). [By Yogesh Goyal and Heath Johnson]